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. 2018 Jul 26;155(3):356–366. doi: 10.1111/imm.12977

Figure 2.

Figure 2

Induced CD11b+ B cells may increase regulatory T (Treg) cells in Peyer's patches (PPs) in vivo. (a) μMT mice were intravenously (i.v.) administered with PP‐derived B cells from wild‐type (WT) mice and CD11b‐deficient mice, respectively, and administered with dextran sulphate sodium (DSS) 2 days later after adoptive transfer. Treg cell percentages (Foxp3+) in PPs within the CD4‐ or CD45‐gated population were detected on day 7 after colitis induction. (b) Purified CD19+ CD11b+ B cells and CD19+ CD11b− B cells in PPs were sorted from colitis mice on day 7 after DSS administration and were adoptively transferred into WT mice. Treg cell percentages (Foxp3+) in PPs within the CD4‐ or CD45‐gated population were detected 4 days later. The number of transferred cells were at 5 × 106 cells suspended in 200 μl sterile phosphate‐buffered saline (PBS). The control group mice receive PBS instead. *P < 0·05; data are representative of six independent experiments.