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. 2018 Sep 4;9(10):1035–1038. doi: 10.1021/acsmedchemlett.8b00334

Table 1. hCA I-XIV Inhibition Data with Famotidine and Acetazolamide (AAZ) as a Standard Inhibitor, by a CO2 Hydration, Stopped-Flow Technique11.

Ki (nM)a
cmpd famotidine AAZ
hCA I 922.4 250.0
hCA II 57.9 12.1
hCA III >10000 >10000
hCA IV 938.8 74.0
hCA VA 1429.5 63.0
hCA VB 5328.2 54.0
hCA VI 98.2 11.0
hCA VII 3.0 2.5
hCA IX 126.3 25.8
hCA XII 45.3 5.7
hCA XIII 171.5 17.0
hCA XIV 677.2 41.0
a

Mean from three different assays, by a stopped-flow technique (errors were in the range of ±5–10% of the reported values).