Table 1. hCA I-XIV Inhibition Data with Famotidine and Acetazolamide (AAZ) as a Standard Inhibitor, by a CO2 Hydration, Stopped-Flow Technique11.
Ki (nM)a | ||
---|---|---|
cmpd | famotidine | AAZ |
hCA I | 922.4 | 250.0 |
hCA II | 57.9 | 12.1 |
hCA III | >10000 | >10000 |
hCA IV | 938.8 | 74.0 |
hCA VA | 1429.5 | 63.0 |
hCA VB | 5328.2 | 54.0 |
hCA VI | 98.2 | 11.0 |
hCA VII | 3.0 | 2.5 |
hCA IX | 126.3 | 25.8 |
hCA XII | 45.3 | 5.7 |
hCA XIII | 171.5 | 17.0 |
hCA XIV | 677.2 | 41.0 |
Mean from three different assays, by a stopped-flow technique (errors were in the range of ±5–10% of the reported values).