. 2018 Sep 14;9(10):1013–1018. doi: 10.1021/acsmedchemlett.8b00283

Table 2. k_inact/K_I Values for Compounds 12a–e, 18, and 24^a.

k_inact/K_I was determined using six concentrations of inhibitor at five different time points. k_inact/K_I was calculated from linear fit of k_obs obtained from two replicates.

k_inact/K_I was calculated from nonlinear regression of k_obs obtained from two replicates. k_obs = k_inact/K_I because [I] ≪ K_I. Cl-amidine under the assay conditions reported here gave the following k_inact/K_I values: PAD1, 4550 ± 860; PAD2, 520 ± 50; PAD3, 2340 ± 80; PAD4, 1770 ± 470.²³ See Supporting Information for further assay details.

Table 2. kinact/KI Values for Compounds 12a–e, 18, and 24a.

Table 2. k_inact/K_I Values for Compounds 12a–e, 18, and 24^a.