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| Cmpd | IV/oral dose (mg/kg) | Cl (mL/min/kg) | Vdss (L/kg) | IV T1/2 (h) | oral Cmax (ng/mL) | oral AUC (ng·h/mL) | %F | free fraction (%) |
|---|---|---|---|---|---|---|---|---|
| GSK583 | 1.0/2.0 | 15 | 2.0 | 7.0 | 260 | 980 | 39 | 2.6 |
| 6 | 2.0/2.0 | 12 | 2.1 | 4.2 | 990 | 3800 | 82 | 11.2 |
