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| species | IV/oral dose (mg/kg) | Cl (mL/min/kg) | Vdss (L/kg) | IV T1/2 (h) | oral Cmax (ng/mL) | oral AUC (ng·h/mL) | %F | free fraction (%) |
|---|---|---|---|---|---|---|---|---|
| rat | 1.1/2.0 | 12 | 1.1 | 3.1 | 740 | 2400 | 85 | 5.5 |
| dog | 1.1/2.0 | 20 | 3.5 | 2.5 | 330 | 1900 | 96 | 16.3 |
| human (predicted) | 1.5a | 6.8 | 1.9 | 6.2 | 259 | 2510 | 74 | 9.6 |
Predicted using average human weight of 70 kg.
