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. 2018 Oct 1;9(10):1019–1024. doi: 10.1021/acsmedchemlett.8b00300

Table 2. Validation of the Binding Mode of Compound 2.

graphic file with name ml-2018-003008_0005.jpg

ID R IC50 (nM)a
2 -H 35.4 ± 1.7
9 -Br 215.0 ± 17.2
10 -F 74.9 ± 8.7
11 -COOEt 1962.5 ± 134.1
a

The IC50 values were determined for each compound (mean ± SEM) from two independent tests.