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. 2018 Sep 4;9(10):1051–1056. doi: 10.1021/acsmedchemlett.8b00361

Table 1. Summarized Activity Data for Hybrid PL Mimics.

compd EC50(μM) max LRH-1 activationa
RJW100 (1) 1.1 ± 0.6 1.47 ± 0.06
11 13 ± 6 2.7 ± 0.3
12g 5 ± 2 2.1 ± 0.1
6HC-CA (13g) 0.4 ± 0.4 2.3 ± 0.2
a

Maximum LRH-1 activation was calculated at the top of the resulting dose–response curves, as a fold increase in LRH-1 activity over baseline (vehicle).