. 2018 Sep 4;9(10):996–1001. doi: 10.1021/acsmedchemlett.8b00245

Table 1. Inhibition Profile of Alkynes against T. brucei^*.

Compare compounds to 3, T. brucei EC₅₀ = 0.26/0.4 μM. EC₅₀ = 0.26 μM is obtained from our initial screening program with parasite concentration of 2 × 10³ cells/mL, and for direct comparison with other compounds, 3 was retested in the same assays that its derivatives were tested in at 5 × 10⁴ cells/mL (EC₅₀ = 0.4 μM).

Ar is 3-chloro-4-((3-fluorobenzyl)oxy)phenyl.

Compounds showing >75% growth inhibition at 5 μM for T. brucei were tested for EC₅₀ values. T. brucei EC₅₀ values are the result of triplicate experiments.

SI is selectivity index = HepG2 TC₅₀/Tbb EC₅₀.

Table 1. Inhibition Profile of Alkynes against T. brucei*.

Table 1. Inhibition Profile of Alkynes against T. brucei^*.