Table 2.
Likelihood of being exposed to an antidepressant in the 365 days after the depression diagnosis and, among exposed individuals, likelihood to be exposed to a first-line guideline-recommended antidepressant, according to material and social neighbourhood deprivation levels.
| Exposure to an antidepressant in the 365 days after diagnosis in the 100,432 study individualsd | Exposure to a first-line guideline-recommended antidepressant among the 65,436 individuals exposed to an antidepressante | |||||
|---|---|---|---|---|---|---|
| Deprivation level | %a | Crude PR (95% CI) | Adjustedb PR (95% CI) | %a | Crude PR (95% CI) | Adjustedc PR (95% CI) |
| Material | ||||||
| Quintile 1 | 61.6 | 1.00 | 1.00 | 88.4 | 1.00 | 1.00 |
| Quintile 2 | 63.7 | 1.03 (1.02-1.05) | 1.02 (1.00-1.04) | 88.9 | 1.01 (1.00-1.02) | 1.00 (0.99-1.01) |
| Quintile 3 | 65.9 | 1.07 (1.05-1.09) | 1.04 (1.02-1.06) | 89.5 | 1.01 (1.00-1.02) | 1.00 (0.99-1.01) |
| Quintile 4 | 66.0 | 1.07 (1.06-1.09) | 1.04 (1.02-1.05) | 88.9 | 1.01 (1.00-1.01) | 0.99 (0.98-1.00) |
| Quintile 5 | 67.4 | 1.09 (1.08-1.11) | 1.04 (1.03-1.06) | 88.9 | 1.01 (1.00-1.01) | 0.99 (0.98-1.00) |
| Social | ||||||
| Quintile 1 | 67.7 | 1.00 | 1.00 | 89.7 | 1.00 | 1.00 |
| Quintile 2 | 68.1 | 1.00 (0.99-1.02) | 1.00 (0.99-1.02) | 89.7 | 1.00 (0.99-1.01) | 1.00 (0.99-1.01) |
| Quintile 3 | 66.3 | 0.98 (0.96-0.99) | 0.98 (0.97-1.00) | 89.2 | 0.99 (0.99-1.00) | 1.00 (0.99-1.01) |
| Quintile 4 | 64.0 | 0.95 (0.93-0.96) | 0.97 (0.95- 0.98) | 89.0 | 0.99 (0.98-1.00) | 1.00 (0.99-1.01) |
| Quintile 5 | 62.6 | 0.92 (0.91-0.94) | 0.96 (0.94-0.97) | 87.8 | 0.98 (0.97-0.99) | 0.99 (0.98-1.00) |
CI = confidence interval; PR = prevalence ratio.
aPercentages of exposed individuals in each quintile.
bAdjusted models for exposure to an antidepressant in the 365 days after depression diagnosis included sex, age, residency area, and year of diagnosis. The model assessing the effect of material deprivation was adjusted for social deprivation, whereas the model assessing the effect of social deprivation was adjusted for material deprivation.
cAdjusted models for exposure to a first-line guideline-recommended antidepressant included sex, age, residency area, year of diagnosis, and specialty of physician who prescribed the initial antidepressant. The model assessing the effect of material deprivation was adjusted for social deprivation, whereas the model assessing the effect of social deprivation was adjusted for material deprivation.
dInformation on deprivation level not available for 4139 individuals.
eInformation on deprivation level not available for 2620 individuals.