Table 3.
Likelihood of persistence with antidepressant drug treatment (ADT) 240 days after initiation and, among persistent individuals, likelihood of compliance with ADT, according to material and social neighbourhood deprivation levels.
| Persistence with ADT 240 days after initiation (n = 65,436)c | Compliance with ADT (≥80% of days covered) among the 35,344 individuals who were persistentd | |||||
|---|---|---|---|---|---|---|
| Deprivation level | %a | Crude PR (95% CI) | Adjustedb PR (95% CI) | %a | Crude PR (95% CI) | Adjustedb PR (95% CI) |
| Material | ||||||
| Quintile 1 | 54.6 | 1.00 | 1.00 | 74.5 | 1.00 | 1.00 |
| Quintile 2 | 55.2 | 1.01 (0.99-1.04) | 1.01 (0.98-1.03) | 75.0 | 1.01 (0.98-1.03) | 1.00 (0.98-1.02) |
| Quintile 3 | 54.4 | 1.00 (0.97-1.02) | 1.00 (0.97-1.02) | 74.4 | 1.00 (0.98-1.02) | 0.99 (0.97-1.01) |
| Quintile 4 | 52.9 | 0.97 (0.95-0.99) | 0.97 (0.95-1.00) | 73.9 | 0.99 (0.97-1.01) | 0.98 (0.96-1.00) |
| Quintile 5 | 53.4 | 0.98 (0.96-1.00) | 0.98 (0.96-1.01) | 74.0 | 0.99 (0.97–1.01) | 0.98 (0.96-1.00) |
| Social | ||||||
| Quintile 1 | 55.3 | 1.00 | 1.00 | 75.7 | 1.00 | 1.00 |
| Quintile 2 | 54.4 | 0.98 (0.96-1.01) | 0.99 (0.96-1.01) | 74.7 | 0.99 (0.97-1.01) | 0.98 (0.96-1.00) |
| Quintile 3 | 53.9 | 0.98 (0.95-1.00) | 0.98 (0.95-1.00) | 75.0 | 0.99 (0.97-1.01) | 0.99 (0.97-1.00) |
| Quintile 4 | 53.7 | 0.97 (0.95-1.00) | 0.98 (0.96-1.01) | 73.8 | 0.98 (0.96-1.00) | 0.98 (0.96-1.00) |
| Quintile 5 | 53.2 | 0.96 (0.94-0.98) | 0.99 (0.96–1.01) | 73.2 | 0.97 (0.95-0.99) | 0.98 (0.96-1.00) |
aPercentages of exposed individuals in each quintile.
bAdjusted models included sex, age, residency area, year of diagnosis, specialty of physician who prescribed the initial antidepressant, therapeutic scheme at initiation (monotherapy/polytherapy), and first-line guideline-recommended antidepressant (yes/no). The model assessing the effect of material deprivation was adjusted for social deprivation, whereas the model assessing the effect of social deprivation was adjusted for material deprivation.
cInformation on deprivation level not available for 2620 individuals.
dInformation on deprivation level not available for 1462 individuals.