Figure 2.

Affinity CTC selection method. (a) The graphic illustration of the NanoVelcro CTC chip of four generations. Reprinted with permission from the authors of [63]; (b) Schematic of the CTC-iChip. The schematic of the workflow begins from the red blood cell filtration, inertial focusing of CTCs, and white blood cells, followed by the removal of white blood cells under a magnetic field. Reprinted with permission from the authors of [16]; (c) The schematic of the microfluidic flow channel of the IsoFlux system. The blood sample mixed with magnetic particles flows through the cartridge, and the circulating tumor cells or other rate cells are enriched and ready for molecular analysis. Reprinted with permission from the authors of [78]; (d) Schematic of polymer-graphene oxide (GO) microfluidic device for capturing the CTCs from the patient blood sample. Reprinted with permission from the authors of [61]; (e) The illustration of the OncoBean Chip shows that the cancer cells are captured on antibody-modified microposts. The inset heatmap shows the velocity decreasing from the centre to the outer edge. Reprinted with permission from the authors of [62].