Figure 4.

Microfluidic system for exosome and nucleic acid analysis. (a) Workflow of microfluidic chip for sample and particle mixing, isolation, and detection of exosomes. Microscope images of immunomagnetic beads for mixing and isolation of exosomes. Reprinted with permission from the authors of [51]; (b) A schematic of ciliated micropillar array for exosome separation. While cells are depleted before entering the region, exosomes are highly enriched by trapping within nanowires. Reprinted with permission from the authors of [100]; (c) An integrated DNA microfluidic analysis device. (Top) Two liquid samples and electrophoresis gel are presented. (Bottom) Optical micrograph of the device from above. Reprinted with permission from the authors of [111].