Figure 8.

Predicted disorder and model of UL37. Shown is predicted flexibility of PRV (A) and HSV-1 UL37FL (B) as calculated by FoldUnfold (http://bioinfo.protres.ru/ogu/) (36). The gray dotted line marked 20.4 is the threshold for the parameter that determines if a residue is folded or unfolded; anything above 20.4 is considered folded and anything below is unfolded. Folded residues are indicated in blue, and unfolded residues are indicated in red. Residues in light blue are treated as folded despite lying below the 20.4 threshold. Binding regions within HSV-1 UL37 are shown for gK/UL20 (light pink), UL36 (cyan), BPAG (purple), RIG-I (green), and TRAF6 (pink). C, model of PRV UL37FL including crystal structure of UL37N (green; PDB code 4K70) and possible conformations of UL37C (blue) based on EOM structures (Fig. 6, C and D).