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. 2018 Aug 27;293(41):16019–16027. doi: 10.1074/jbc.RA118.004102

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© 2018 Shares et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 3. — Up-regulation of mitochondrial OxPhos by replacing glucose with galactose stimulates β-catenin signaling. C3H cells were transfected with the indicated reporters and assessed for luciferase signal after 48-h incubation in either glucose (Glc) or galactose (Gal) medium. Stimulation of OxPhos by replacing media glucose with galactose resulted in significant up-regulation of the β-catenin (β-cat) reporter (A) and expression of β-catenin target genes Axin2 and Dkk1 (B). The dashed line indicates glucose control. Data are means. Error bars represent S.E. (n = 3–5). *, p < 0.05 compared with 48-h glucose control. RLU, relative luciferase units.