Figure 5.

The effect of medium volume flow rate Q on (A) oxygen and (B) glucose concentration profiles in the center of spheroid along x-axis (defined based on the dimensionless x position: x/D). The effect of changing the flow rate is more pronounced on the oxygen concentration compared to that on the glucose. When the medium flow rate increases by 300%, the maximum concentrations of oxygen and glucose increase by 38% and 1%, respectively. The simulations were carried out for D = 500 μm, $c_{0,O_2}=0.2\mathrm{mM}$ and $c_{0,glucose}=11\mathrm{mM}$.