Table 6.

Toxicity properties analysis of ciprofloxacin, ofloxacin, lomefloxacin, and norfloxacin compounds

Drug	Ames toxicity	Max. tolerated dose (human)	hERG I inhibitor	hERG II inhibitor	Oral rat acute toxicity (LD50)	Oral rat chronic toxicity (LOAEL)	Hepato toxicity	Skin sensitisation	Tetrahymena pyriformis toxicity	Minnow toxicity
Ciprofloxacin	Yes	−0.264	No	No	2.311	1.557	Yes	No	0.344	1.647
Norfloxacin	No	0.341	No	No	2.222	1.003	Yes	No	0.292	1.3
Ofloxacin	No	0.398	No	No	2.237	1.774	Yes	No	0.286	1.475
Lomefloxacin	Yes	0.529	No	No	2.216	1.755	Yes	No	0.29	1.218