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. 2018 Oct 11;10:4371–4380. doi: 10.2147/CMAR.S171126

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© 2018 Guo et al. This work is published and licensed by Dove Medical Press Limited

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NEAT1 knockdown and miR-214-3p overexpression inhibited DOX resistance in UBC J82/DOX and T24/DOX cells.

Notes: (A, B) IC50 values of DOX in J82/DOX and T24/DOX cells with their parental cells; (C, D) qRT-PCR analysis of the knockdown and overexpression efficiency of NEAT1 and miR-214-3p in J82/DOX and T24/DOX cells; (E, F) Western blot assay shows the expression level of P-gp in J82/DOX and T24/DOX cells; (G, H) CCK-8 assay shows the IC50 value of DOX in J82/DOX and T24/DOX cells; (I, J) Flow cytometry assay shows the apoptotic rate of J82/DOX and T24/DOX cells. *P<0.05, **P<0.01.

Abbreviations: NEAT1, nuclear-enriched abundant transcript 1; DOX, doxorubicin; UBC, urothelial bladder cancer; si-con, scrambled control; si-NEAT1, siRNAs of NEAT1; GAPDH, glyceraldehyde 3-phosphate dehydrogenase.