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. 2018 Oct 11;10:4371–4380. doi: 10.2147/CMAR.S171126

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© 2018 Guo et al. This work is published and licensed by Dove Medical Press Limited

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NEAT1-induced inhibition on DOX resistance in UBC was mediated by miR-214-3p.

Notes: J82/DOX and T24/DOX cells were transfected with si-NEAT1 and anti-miR-214-3p or matched controls. (A, B) Western blot analysis shows the expression level of P-gp in J82/DOX and T24/DOX cells; (C, D) CCK-8 assay shows the IC50 value of DOX in J82/DOX and T24/DOX cells; (E, F) Flow cytometry assay shows the apoptotic rate of J82/DOX and T24/DOX cells. *P<0.05. #P<0.01.

Abbreviations: NEAT1, nuclear-enriched abundant transcript 1; DOX, doxorubicin; UBC, urothelial bladder cancer; si-con, scrambled control; si-NEAT1, siRNAs of NEAT1; GAPDH, glyceraldehyde 3-phosphate dehydrogenase.