Table 1.
Wildtype | Stab1−/− | ||
---|---|---|---|
BONE MARROW | |||
Pre-pro (B220+ CD24low CD43+) | 15.8 ± 1.1a (n = 5) | 10.7 ± 0.9a (n = 5) | *b |
Pre (B220+ CD24+ CD43− IgM− IgD−) | 20.2 ± 2.1a (n = 5) | 13.0 ± 2.1a (n = 5) | ***b |
Immature (B220+ CD24+ CD43− IgMlow IgD−) | 7.7 ± 0.2a (n = 5) | 7.7 ± 0.2a (n = 5) | |
Early mature (B220+ CD24+ CD43− IgM+ IgD+) | 27.9 ± 0.6a (n = 5) | 21.1 ± 0.4a (n = 5) | ***b |
Late mature (B220+ CD24+ CD43− IgMlow IgD+) | 3.1 ± 0.2a (n = 5) | 4.4 ± 0.4a (n = 5) | |
Transitional (B220+ CD24+ CD43− IgM+ IgD−) | 9.9 ± 0.4a (n = 5) | 8.7 ± 0.6a (n = 5) | |
Plasma cells (CD45+ B220low CD138high) | 44.9 ± 2.5a (n = 5) | 44.1 ± 0.8a (n = 5) | |
B1 cells (CD19+ CD5+/− CD11b+) | 3.2 ± 0.5a (n = 8) | 3.4 ± 0.2a (n = 9) | |
BLOOD | |||
B220+ B cells | 42.2 ± 5.3a (n = 9) | 60.6 ± 3.4a (n = 9) | *c |
PERITONEAL CAVITY | |||
B1 cells (CD19+ CD5+/− CD11b+) | 39.3 ± 4.1a (n = 8) | 22.4 ± 2.3a (n = 9) | **c |
% of cells (mean ± SEM).
*P < 0.05, ***P < 0.001 (two-way ANOVA).
*P < 0.05, **P < 0.01 (Student's unpaired two-tailed t-test with Welch's correction).