Table 3.

Analyses of mediation of the relationship between genotype and AUDIT total score

(a) rs755658
Mediator	PAMS total score					PAMS1
	Effect	SE	95% CI	t	P-value	Effect	SE	95% CI	t	P-value
Total effect	1.08	0.554	(−0.004; 2.17)	1.96	0.051	1.08	0.554	(−0.004; 2.17)	1.96	0.051
Direct effect	0.293	0.499	(−0.69; 1.27)	0.59	0.556	0.33	0.505	(−0.66; 1.03)	0.66	0.509
	Effect	SE	Bootstrapped 95% CI	Significance		Effect	SE	Bootstrapped 95% CI	Significance
Indirect effect	0.79	0.289	(0.272; 1.394)	Significant		0.75	0.27	(0.24; 1.32)	Significant

(b) rs1334894
Mediator	PAMS total score					PAMS1
	Effect	SE	95% CI	t	P-value	Effect	SE	95% CI	t	P-value
Total effect	1.17	0.55	(0.088; 2.25)	2.12	0.034	1.17	0.55	(0.088; 2.25)	2.12	0.034
Direct effect	0.376	0.496	(−0.6; 1.35)	0.75	0.449	0.42	0.503	(−0.57; 1.41)	0.83	0.405
	Effect	SE	Bootstrapped 95% CI	Significance		Effect	SE	Bootstrapped 95% CI	Significance
Indirect effect	0.79	0.28	(0.3; 1.38)	Significant		0.75	0.26	(0.26; 1.29)	Significant

Abbreviations: AUDIT, Alcohol Use Disorders Identification Test; PAMS, Positive Alcohol Metacognitions Scale.