Table 3.

Correlation of mRNA expression of genes identified by COMPARE analysis with log₁₀IC₅₀ values of bromocriptine for 60 NCI tumor cell lines^a.

COMPARE coefficient	Pattern ID	GeneBank accession	Gene symbol	Gene name	Gene function
0.642	GC38764	X60489	EEF1B2	Eukaryotic translation elongation factor 1β2	Stimulates the exchange of GDP bound to EF1α to GTP.
0.640	GC39380	U09953	RPL9	Ribosomal protein L9	ribosomal protein L9
0.627	GC35297	M31520	RPS24	Ribosomal protein S24	Required for processing of pre-rRNA and maturation of 40S ribosomal subunits
0.622	GC33697	M84711	RPS3A	Ribosomal protein S3A	Role during erythropoiesis by regulation of transcription factor DDIT3
0.616	GC29122	AF054183	RAN	RAN, member RAS oncogene family	Mediation of nucleocytoplasmic protein and ribonucleoprotein transport
0.612	GC36652	L38941	RPL34	Ribosomal protein L34	60S ribosomal protein L34
0.604	GC34926	X79563	RPS21	Ribosomal protein S21	40S ribosomal protein S21, 9 kDa
0.598	GC37574	S79522	RPS27A	Ribosomal protein S27a	60S ribosomal protein S27A. Component of the 40S subunit of the ribosome
0.596	GC30163	AF054187	NACA	Nascent polypeptide-associated complex α subunit	Regulation of myotube development. Role in ventricular cardiomyocyte expansion and postnatal skeletal muscle growth and regeneration
0.593	GC37319	W52024	RPS15A	Ribosomal protein S15a	60S ribosomal protein S15A
0.592	GC34223	M14199	RPSA	Ribosomal protein SA	Required for the assembly and stability of the 40S ribosomal subunit. Cell surface receptor for laminin. Cell adhesion to the basement membrane and activation of signaling transduction
0.590	GC36135	X99226	FANCA	Fanconi anemia, complementation group A	Interstrand DNA cross-link repair and maintenance of chromosome stability
0.585	GC28763	AF016371	PPIH	Peptidylprolyl isomerase H (cyclophilin H)	Protein folding
0.576	GC30155	Z23064	RBMX	RNA binding motif protein, X-linked	Regulation of gene transcription and alternative splicing of several pre-mRNAs
0.575	GC29002	M14630	PTMA	Prothymosin α	Mediation of immunological resistance to certain opportunistic infections
0.574	GC34930	X69391	RPL6	Ribosomal protein L6	Specifically binds to domain C of the tax-responsive enhancer element in the long terminal repeat of HTLV-I
0.571	GC27651	AB007191	MYCBP	C-myc binding protein	May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC
0.571	GC29848	T79616	UQCRB	Ubiquinol-cytochrome c reductase binding protein	A component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain
0.570	GC35323	U37230	RPL23A	Ribosomal protein L23a	Binds 26S rRNA
0.567	GC35222	TARDBP	AL050265	TAR DNA binding protein	DNA and RNA-binding protein regulating transcription and splicing
-0.612	GC33001	U11872	CXCR2	Chemokine (C-X-C motif) receptor 2	IL8 receptor activating neutrophils
-0.546	GC35931	X13255	DBH	Dopamine β-hydroxylase (dopamine β-monooxygenase)	Activity is enhanced by nerve growth factor
-0.545	GC27591	D87463	PHYHIP	Phytanoyl-CoA 2-hydroxylase interacting protein	Role in the development of the central system
-0.544	GC28151	U15780	ST5	Suppression of tumorigenicity 5	Guanine nucleotide exchange factor (GEF) activating RAB9A and RAB9B
-0.516	GC31384	AF035812	DYNC1LI2	Dynein, cytoplasmic 1, light intermediate chain 2	Component of the cytoplasmic dynein 1 complex that is involved cargo transport
-0.495	GC29420	Z50022	PTTG1IP	Pituitary tumor-transforming 1 interacting protein	Facilitates PTTG1 nuclear translocation by transcription factor RUNX2
-0.479	GC30117	W27517	TMEM109	Transmembrane protein 109	DNA damage response. Protection against ultraviolet C-induced cell death
-0.476	GC38293	M33680	CD81	Cluster of differentiation molecule 81	Signal transducer. Viral receptor for HCV
-0.476	GC29175	AA487755	FKBP9	FK506 binding protein 9, 63 kDa	Protein folding during protein synthesis
-0.476	GC36401	AB023151	DIP2C	DIP2 disco-interacting protein 2 homologue C (Drosophila)	Transcription factor binding
-0.474	GC31394	AB011171	PLEKHG3	Pleckstrin homology domain containing, family G (with RhoGef domain) member 3	Rho guanyl-nucleotide exchange factor
-0.474	GC38796	AF035292	OBSL1	Obscurin-like 1	Role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain
-0.473	GC33621	Y00285	IGF2R	Insulin-like growth factor 2 receptor	Transport of phosphorylated lysosomal enzymes from Golgi complex and cell surface to lysosomes
-0.472	GC36838	R48209	FAM214B	Family with sequence similarity 214 member B	Function unknown
-0.470	GC35831	AF104913	EIF4G1	Eukaryotic translation initiation factor 4γ1	Component of the eIF4F complex, which is involved in the recruitment of mRNA to the ribosome
-0.469	GC32200	AL096879	TMEM184B	Transmembrane protein 184B	Activation of MAP kinase signaling
-0.467	GC31388	S80562	CNN3	Calponin 3, acidic	Thin filament-associated protein modulating smooth muscle contraction. Binds actin, calmodulin, troponin C, and tropomyosin
-0.465	GC32482	M31724	PTPN1	Protein tyrosine phosphatase, non-receptor type 1	Role in CKII- and p60c-src-induced signal transduction cascades. Regulation of EFNA5-EPHA3 signaling, which modulates cell reorganization and cell-cell repulsion. Regulation of hepatocyte growth factor receptor signaling by MET dephosphorylation
-0.461	GC32085	AB018333	SASH1	SAM and SH3 domain containing 1	Signal transducer, tumor suppressor
-0.459	GC32336	X07767	PRKACA	Protein kinase, cAMP-dependent, catalytic, α	Phosphorylation of cytoplasmic and nuclear proteins

^aPositive correlation coefficients indicated direct correlations to log₁₀ IC₅₀ values; negative ones indicated inverse correlations. Information on gene functions was taken from the OMIM database, NCI, United States (http://www.ncbi.nlm.nih.gov/Omim/) and from the GeneCard database of the Weizman Institute of Science, Rehovot Israel (https://www.genecards.org/).