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. 2018 Sep 21;9(74):33947–33960. doi: 10.18632/oncotarget.26103

Figure 3. Tcf/LEF dependent β-catenin-signalling in HBV-replicating hepatoma cells.

Figure 3

Relative luciferase activity indicates the level of Tcf/LEF dependent β-catenin-signalling (grey bars) in parental (−) or H1.3x or H1.3x− (a) replicating HepG2 and (b) transfected Huh7 cells. Ratios in parental cells were set to 1. Active viral replication was determined by measuring HBV rcDNA (white bars) levels in supernatants of HBV-producing cells. The assays were performed in independent triplicates, means + SD are shown. ** p<0.01 vs parental cells, t-test. (c) c-myc and HBV core protein levels were subjected to Western blot analysis in parental (−) compared to HBV-replicating (H1.3 + H1.3x−) HepG2 cells.