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. 2018 Oct 10;10:4421–4438. doi: 10.2147/CMAR.S176088

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© 2018 Chen et al. This work is published and licensed by Dove Medical Press Limited

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Endogenous LINE-1 ORF-1p mRNA levels in advanced HCC clinical specimens in relation to the prognosis of patients who received sorafenib treatment. Notes: (A and B) Endogenous mRNA expression of LINE-1 ORF-1p was identified using qPCR for relative RNA levels (A) or representative DNA electrophoresis bands from ten representative specimens (five high and five low) (B). (C) The OS and (D) TTP of patients who received sorafenib are shown. (C and D) Significant differences in the survival analysis were assessed using the Kaplan–Meier and log-rank tests. ^*P<0.05.

Abbreviations: Cum, cumulative; HCC, hepatocellular carcinoma; OS, overall survival; qPCR, quantitative PCR; TTP, time to progression.