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LINE-1 ORF-1p decreased the antitumor effect of sorafenib in inhibiting LM-3 cell subcutaneous growth in vivo.
Notes: LM-3 cells, which were transfected with an empty vector, a full-length LINE-1 ORF-1p vector, LINE-1 ORF-1p 1–160 residues, control siRNA or LINE-1 ORF-1p siRNA vectors, were seeded into nude mice to form subcutaneous tumors. The mice received sorafenib. (A) The results are shown as representative photographs of tumors, (B) tumor volumes or (C) tumor weight. *P<0.05.
