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. 2018 Oct 10;10:4421–4438. doi: 10.2147/CMAR.S176088

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© 2018 Chen et al. This work is published and licensed by Dove Medical Press Limited

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LINE-1 ORF-1p decreased the antitumor effect of sorafenib in inhibiting LM-3 cell intrahepatic growth in vivo.

Notes: LM-3 cells, which were transfected with an empty vector, a full-length LINE-1 ORF-1p vector, LINE-1 ORF-1p 1–160 residues, control siRNA or LINE-1 ORF-1p siRNA vectors, were seeded into nude mouse livers via the hepatic portal vein to form intrahepatic tumors. (A) The mice received sorafenib and were screened using PET/CT. (B) The results are shown as representative photographs of livers with nodules formed by LM-3 cells, (C) the radioactivation of liver to blood or (D) the relative nodule area. ^*P<0.05.

Abbreviation: PET/CT, positron emission tomography/computed tomography.