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LINE-1 ORF-1p enhanced the transcription factor activation of PXR in HCC cells.
Notes: (A and B) MHCC97-H cells were co-transfected with empty vector and LINE-1 ORF-1p vectors, PXRE-Luc (A) or XREM-Luc (B). (C and D) MHCC97-H cells were co-transfected with control siRNA and LINE-1 ORF-1p siRNA, PXRE-Luc (C) or XREM-Luc (D). Cells were harvested for luciferase analysis. *P<0.05.
Abbreviations: HCC, hepatocellular carcinoma; PXR, pregnenolone X receptor.
