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. 2018 Oct 10;10:4421–4438. doi: 10.2147/CMAR.S176088

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© 2018 Chen et al. This work is published and licensed by Dove Medical Press Limited

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The LINE-1 ORF-1p C–C domain can interact with the PXR LBD.

Notes: (A) MHCC97-H cells were transfected with full-length FLAG-PXR or truncated mutants of PXR and HA-tagged LINE-1 ORF1-p. (B) MHCC97-H cells, which were transfected with full-length FLAG-LINE-1 ORF-1p or truncated mutants of LINE-1 ORF-1p and HA-tagged PXR, were lysed and immunoprecipitated with an anti-FLAG antibody. IB analysis was then performed using an anti-HA antibody.

Abbreviations: IB, immunoblotting; IP, immunoprecipitation; LBD, ligand-binding domain; PXR, pregnenolone X receptor.