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. 2018 Oct 10;10:4421–4438. doi: 10.2147/CMAR.S176088

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© 2018 Chen et al. This work is published and licensed by Dove Medical Press Limited

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LINE-1 ORF-1p decreased the antitumor effect of sorafenib in inhibiting MHCC97-H cell subcutaneous growth in vivo.

Notes: MHCC97-H cells, which were transfected with empty vector, a full-length LINE-1 ORF-1p vector, LINE-1 ORF-1p 1–160 residues, control siRNA or LINE-1 ORF-1p siRNA vectors, were seeded into nude mice to form subcutaneous tumors. The mice received sorafenib. (A) The results are shown as representative photographs of tumors, (B) tumor volumes or (C) tumor weight. ^*P<0.05.