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LINE-1 ORF-1p expression and clinical outcome of sorafenib treatment
| LINE-1 ORF-1p mRNA expression | P-value | ||
|---|---|---|---|
| High (n=24) | Low (n=28) | ||
|
| |||
| TTP | 8.0 | 11.0 | 0.0002 |
| 6.8–10.6 months | 9.1–12.0 months | ||
| OS | 10.0 | 14.0 | 0.0381 |
| 6.1–13.8 months | 11.4–16.3 months | ||
| Overall response rate (PR) | 1 (4.17%) | 3 (10.71%) | |
| Disease control rate (PR+SD) | 4 (16.67%) | 9 (32.14%) | |
Abbreviations: CR, complete remission; OS, overall survival; PR, partial remission; SD, stable disease; TTP, time to progression.
