Table 1.
Various product types as alternatives to antibiotics for the therapeutic management of bacterial infections
| Target bacteria | Product name | Product type | Company | References |
|---|---|---|---|---|
| Clostridium difficile | AmpliPhage-004 | Bacteriophages | AmpliPhi Biosciences | 113 |
| Phenylbutyrate/vitamin D | Immune stimulator | Akthelia Pharmaceuticals | 114, 115 | |
| C. difficile toxoid vaccine | Vaccine | Sanofi Pasteur | 116 | |
| IC84 | Vaccine | Valneva | 117 | |
| NVB302 | Antimicrobial peptides | Novacta Biosystems | 118 | |
| AP-114 | Antimicrobial peptides | Adenium Biotech | 119 | |
| Bezlotoxumab | Antibodies | Merck | 120, 121 | |
| RBX2660 | Probiotics | Rebiotix | 122 | |
| SER-109 | Probiotics | Seres Therapeutics | 123 | |
| VP20621 | Probiotics | ViroPharma (Shire) | 124 | |
| Staphylococcus aureus | SA4Ag | Vaccines | Pfizer | 125 |
| AP-138 | Antimicrobial peptide | Adenium Biotech | 119 | |
| SAL200 | Lysins | iNtRON Biotechnology | 126 | |
| CF-301 | Lysins | ContraFect | 127 | |
| MEDI4893 | Antibodies | MedImmune | 121, 128 | |
| Salvecin | Antibodies | Aridis Pharmaceuticals | 129 | |
| 514G3 | Antibodies | XBiotech | 130 | |
| Pseudomonas aeruginosa | AmpliPhage-001 | Bacteriophages | AmpliPhi Biosciences | 131 |
| PT-3.1 | Bacteriophages | Phico Therapeutics | 132 | |
| IC43 | Vaccines | Valneva | 133 | |
| Murepavadin | Antimicrobial peptides | Roche | 134 | |
| Aerumab | Antibodies | Aridis Pharmaceuticals | 135 | |
| Aerucin | Antibodies | Aridis Pharmaceuticals | 136 | |
| MEDI3902 | Antibodies | MedImmune | 137 |