Table 1. Comparison of autophagy types.
Macroautophagy | Selective autophagy - mitophagy | Chaperone-mediated autophagy | Microautophagy | |
---|---|---|---|---|
Autophagosome formation | Formed | Formed | Not formed | Not formed |
Degradation of substrate in lysosome | Yes | Yes | Yes | Yes |
Key proteins regulating the process | BECN1, proteins from the ATG family | PINK1 | LAMP2 | Not identified |
Process selectivity | Non-specific process | Mitophagy - specific for mitochondria | Applies only to substrates containing a KFERQ sequence | Process specific to very small organelles |