Table 1. Impact of complex karyotype on OS.
| Tot. pts | CK | Treatment | Disease status | Median OS (months) |
Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Reference | CK yes | CK no | HR (IC 95%) | P | HR (IC 95%) | P | ||||
| [20] | 109 | NA | various | TN and pretreated | 107 | 346 | 15.44* | <0.001 | - | Ø |
| [38] | 482 | 71/399 (17.8%) |
NA | TN | 81.1% at 5y | 86-94.4% at 5y # |
3.830 (1.714-8.560) |
0.001 | - | Ø |
| [73] | 284 | 22/182 (12.1%) |
FCR | R/R | 26 | 10.5 m. -78 m. ## |
- | - | 1.9 (1.1-3.2) |
0.015 |
| [74] | 80 | 8/67 (11.9%) |
CFAR | R/R | NA | NA | - | - | 2.0 (1.1-3.7)** |
0.022 |
| [72] | 38 | 16/38 (42.1%) |
NA | TN | 56 | 144 | - | - | - | - |
| [39] | LC 166 VC 250 |
20/145 (13.8%) 35/238 (14.7%) |
various | TN | NA | NA | 2.701 (1.988-8.787) 2.155 (1.160-4.004) |
<0.001 0.015 |
4.856 (1.475-9.998) 3.630 (1.358–9.703) |
<0.0001 0.010 |
| [29] | 110 | 38/110 (34.5%) |
FCR | TN | 72.4% at 5 y | 85.8% at 5y | - | - | 5.16 (1.2-22.1) |
0.07 |
| [24] | 161 | 30/154 (19.5%) |
Clb/Clb-R/Clb-G | TN | NA | NA | 2.9 (1.5-5.4)° 2.6 (1.3-5.4)°° |
0.001° 0.006°° |
2.682 (1.366-5.264) |
0.004 |
| [63]# | 1045 | 99/1043 (9.5%) |
various | TN | 79 | NR | - | - | 1.66 (1.06-2.59) |
0.027 |
| [27] | 335 | 41/287 (14.3%) |
various | TN | 70 | 135 | 3.176 (1.882-5.359) | <0.001 | 3.572 (1.341-9.515) |
0.011 |
| [77] | 186 | 37/186 (19.8%) |
Lenalidomide-R Lenalidomide-O |
R/R | 23 | 62.8 | - | - | 2.08 (1.15-3.76) |
0.015 |
TN=treatment naïve; R/R= relapsed/refractory; OS=overall survival; CK=complex karyotype; NA=not available; Clb=chlorambucil; FCR=Fludarabine, Cyclophosphamide, Rituximab; G=Obinutuzumab; R= Rituximab; O-Ofatumumab; Ø=not significant; LC: learning cohort; VC: validation cohort
*log rank; **CK or 17p aberration; °all arms; °°(Clb-R+Clb-G);
#MBL/CLL
# OS was compared in this study between patients with CK and patients without CK carrying chromosome translocations, or 1-2 aberrations or normal karyotype.
## OS in the patients without CK was reported in this study according to the aberration detected by FISH (13q-, +12, 11q-, 17p).