Table 3.

Domains of factors of adherence to rhGH studied in 11 reports (2011–2017)

Reference	Descriptive factors	Individual factors	Social factors	Practical factors	Health care factors	No domains	Factors suggested in the discussion section of the articles
Bagnasco et al (2017)18 Endocrine Practice	x	x	x	x	x	5
Gau and Takasawa (2017)19 Journal of Pediatric Endocrinology and Metabolism	x			x		2	Socioeconomic factors (eg, mother’s education level) Type of device Pubertal stage
Auer et al (2016)20 Clinical Endocrinology	x			x		2	Forgetfulness Side effects of treatment Perceived treatment benefits Physician–patient relationship Patient education
de Pedro et al (2016)21 Growth Hormone & IGF Research	x					1
Kappelgaard et al (2015)22 Expert Review of Medical Devices				x		1	Choice of device Easy-to-use device
Lass and Reinehr (2015)23 Hormone Research in Paediatrics	x			x		2	Education level Psychological and emotional problems Social issues Technical handling issues Misconceptions about consequences of missed doses Discomfort with injections Dissatisfaction with results Inadequate contact with HCPs
Spoudeas et al (2014)24 Patient Preference and Adherence	x				x	2	Lack of choice of delivery device Person who administers the dose Injection discomfort or anxiety Patient support (injection training and contact with HCP) Too much involvement in treatment decisions
Aydın et al (2014)25 Endocrine Practice	x			x		2	Neglecting to renew the prescription Forgetting to administer the drug Vacation/break from taking the medication Problems with the delivery device
Hartmann et al (2013)26 Hormone Research in Paediatrics	x					1	Education Psychological, emotional, and social problems Delivery device Support for adolescents and their families
Bozzola et al (2011)27 BMC Endocrine Disorders	x				x	2	Duration of treatment (participants become less enthusiastic and motivated) Misperceptions about the consequences of missed GH doses Discomfort with injections Dissatisfaction with treatment results Inadequate contact with HCP Patient not involved in treatment decisions Choice of the delivery device Use of complicated delivery devices Experience with the delivery device
Cutfield et al (2011)28 PLoS One	x					1	Injection frequency Type of device Lack of perceived benefits Lack of perceived risks of noncompliance Culture and socioeconomic factors

Abbreviations: GH, growth hormone; HCP, Health Care Professionals; rhGH, recombinent human GH.