Table 5.
Domains of factors of adherence to prophylaxis treatment in hemophilia in 16 reports (2011–2017)
| Reference | Descriptive factors | Individual factors | Social factors | Practical factors | Health care factors | No domains | Factors suggested in the discussion |
|---|---|---|---|---|---|---|---|
| Tran et al (2017)29 Haemophilia |
x | x | 2 | Family support Social support Social stigma Necessity beliefs Concern beliefs Health-system factors: individual formularies, prior-authorization requirements, cost sharing |
|||
| van Os et al (2017)30 PLoS ONE |
x | x | 2 | Treatment cost | |||
| Lock et al (2016)31 Haemophilia |
x | 1 | Communication between parents and the treatment center | ||||
| Mclaughlin et al (2016)32 Racial and Ethnic Health Disparities |
0 | NA | |||||
| Miesbach and Kalnins (2016)33 Haemophilia |
x | x | 2 | Infusion timing Frequency of infusions Perceived benefits of treatment |
|||
| Schrijvers et al (2016)34 British Journal of Haematology |
x | 1 | Accepting the disease Self-management skills Infusion timing |
||||
| Witkop et al (2016)35 Haemophilia |
x | 1 | Attitudes toward prophylaxis treatment Parental support Motivation and encouragement Sense of normality (treatment is normal) Perceived benefits, experience of results |
||||
| García-Dasí et al (2015)36 Haemophilia |
x | x | x | x | x | 5 | Puberty Emotional aspects Accepting the disease Family attitude: watchfulness vs overprotection |
| Mingot-Castellano et al (2015)37 Blood Coagulation and Fibrinolysis |
x | 1 | NA | ||||
| Schrijvers et al (2015)38 Haemophilia |
x | x | x | 3 | Perception of self-monitoring Self-management skills Age (position of hemophilia in adolescent patients) |
||
| Lamiani et al (2015)39 Haemophilia |
x | x | 2 | NA | |||
| Ho et al (2014)40 Haemophilia |
x | 1 | Intensity of treatment regimen Cost of treatment |
||||
| Tang et al (2013)41 Haemophilia |
x | x | 2 | Economic constraint Limitation in factor concentrate availability Education (potential benefits on the child’s well-being and quality of life) |
|||
| Duncan et al (2012)42 Haemophilia |
x | 1 | Transition points: shift from infused by family or nurse to self-infusion and switch from a prophylaxis regimen to on-demand treatment | ||||
| Thornburg et al (2012)43 Haemophilia |
x | 1 | Financial concerns Accessibility of treatment Self-infusion vs other-infusion Education Frequency of infusion |
||||
| Zappa et al (2012)44 Haemophilia |
x | x | x | 3 | NA |
Abbreviation: NA, not available.