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. 2018 Oct 10;10:4459–4470. doi: 10.2147/CMAR.S177373

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© 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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TGF-β1 mediates the promoting role of SALL4 in gastric cancer cell migration and invasion.

Notes: (A, B) qRT-PCR (A) and Western blot (B) analyses of TGF-β1 expression in SALL4-overexpressing HGC-27 cells with or without TGF-β1 knockdown. (C, D) Cell scratch assay for the motility of SALL4-overexpressing HGC-27 cells with or without TGF-β1 knockdown (C) or HY-P0118 treatment (D). (E, F) Transwell migration and Matrigel invasion assays for the migration and invasion abilities of SALL4-overexpressing HGC-27 cells with or without TGF-β1 knockdown (E) or HY-P0118 treatment (F). (G, H) qRT-PCR (G) and Western blot (H) analyses of EMT markers and SMAD2/3 in SALL4-overexpressing HGC-27 cells with or without TGF-β1 knockdown. *P<0.05, **P<0.01, ***P<0.001, compared to vector group; ^#P<0.05, ^##P<0.01, ^###P<0.001, compared to SALL4 group.

Abbreviations: EMT, epithelial–mesenchymal transition; qRT-PCR, quantitative real-time PCR.