Table 5.
Baseline BPs and mean BP decreases from baseline of hypertensive populations with drug compliance
| Group | SBP (mmHg)
|
DBP (mmHg)
|
||||
|---|---|---|---|---|---|---|
| At baseline | Mean decrease from baselinea | P-value for change | At baseline | Mean decrease from baselinea | P-value for change | |
| Rushan | ||||||
| CCB (n=2,588) | 154.3±20.5 | 18.7 (17.8 to 19.6) | <0.001 | 91.9±11.3 | 9.8 (9.3 to 10.3) | <0.001 |
| D (n=725) | 157.9±21.1 | 23.1 (21.5 to 24.7) | <0.001 | 92.5±11.6 | 10.6 (9.7 to 11.5) | <0.001 |
| BB (n=145) | 147.4±18.3 | 16.0 (12.7 to 19.3) | <0.001 | 89.7±10.3 | 8.5 (6.7 to 10.3) | <0.001 |
| ACEI (n=1,613) | 157.8±20.0 | 21.6 (20.5 to 22.7) | <0.001 | 93.7±10.9 | 10.6 (10.0 to 11.2) | <0.001 |
| ARB (n=388) | 146.2±18.6 | 10.3 (8.3 to 12.3) | <0.001 | 90.8±11.9 | 8.0 (6.7 to 9.3) | <0.001 |
| S1 (n=0) | – | – | – | – | – | – |
| C1 (n=1,027) | 157.0±21.8 | 18.1 (16.6 to 19.6) | <0.001 | 93.5±12.1 | 10.0 (9.2 to 10.8) | <0.001 |
| S2 (n=2,362) | 157.2±20.9 | 20.5 (19.6 to 21.4) | <0.001 | 93.0±11.2 | 10.1 (9.6 to 10.6) | <0.001 |
| Subtotal (n=8,848) | 155.9±20.8 | 19.6 (19.1 to 20.1) | <0.001 | 92.7±11.4 | 10.0 (9.7 to 10.3) | <0.001 |
| Taixing | ||||||
| CCB (n=5,257) | 138.6±16.4 | 4.6 (4.1 to 5.1) | <0.001 | 85.6±9.8 | 2.7 (2.4 to 3.0) | <0.001 |
| D (n=132) | 139.4±18.1 | 5.5 (2.5 to 8.5) | 0.001 | 85.7±10.3 | 3.0 (1.1 to 4.9) | 0.003 |
| BB (n=175) | 140.2±15.9 | 7.6 (5.1 to 10.1) | <0.001 | 85.6±9.8 | 3.6 (2.0 to 5.2) | <0.001 |
| ACEI (n=9,735) | 140.6±17.7 | 5.8 (5.4 to 6.2) | <0.001 | 86.0±10.5 | 3.0 (2.8 to 3.2) | <0.001 |
| ARB (n=231) | 138.9±17.3 | 3.7 (1.2 to 6.2) | 0.004 | 85.6±10.8 | 2.1 (0.6 to 3.6) | 0.006 |
| S1 (n=4,596) | 141.5±17.9 | 6.8 (6.3 to 7.3) | <0.001 | 86.1±10.4 | 3.0 (2.7 to 3.3) | <0.001 |
| C1 (n=2,000) | 143.7±18.8 | 5.7 (4.8 to 6.6) | <0.001 | 87.7±11.2 | 2.8 (2.3 to 3.3) | <0.001 |
| S2 (n=17,849) | 140.3±17.1 | 5.7 (5.4 to 6.0) | <0.001 | 85.3±10.1 | 2.6 (2.4 to 2.8) | <0.001 |
| Subtotal (n=39,975) | 140.5±17.4 | 5.7 (5.5 to 5.9) | <0.001 | 85.7±10.3 | 2.7 (2.6 to 2.8) | <0.001 |
| Yuhu | ||||||
| CCB (n=16,243) | 133.3±17.2 | 4.4 (4.1 to 4.7) | <0.001 | 81.1±10.0 | 2.9 (2.7 to 3.1) | <0.001 |
| D (n=1,504) | 130.3±16.5 | 3.5 (2.6 to 4.4) | <0.001 | 80.9±9.6 | 3.1 (2.5 to 3.7) | <0.001 |
| BB (n=567) | 133.8±16.7 | 5.0 (3.5 to 6.5) | <0.001 | 80.8±8.8 | 3.1 (2.3 to 3.9) | <0.001 |
| ACEI (n=3,221) | 134.6±18.2 | 5.4 (4.7 to 6.1) | <0.001 | 82.3±10.4 | 4.1 (3.7 to 4.5) | <0.001 |
| ARB (n=656) | 132.6±15.4 | 4.1 (2.8 to 5.4) | <0.001 | 80.3±9.6 | 2.7 (1.3 to 4.1) | <0.001 |
| S1 (n=1,074) | 132.9±15.2 | 3.4 (2.3 to 4.5) | <0.001 | 81.6±9.4 | 2.8 (2.2 to 3.4) | <0.001 |
| C1 (n=350) | 136.7±19.6 | 4.7 (2.4 to 7.0) | <0.001 | 82.7±10.8 | 2.9 (1.6 to 4.2) | <0.001 |
| S2 (n=4,372) | 134.1±17.5 | 3.6 (3.0 to 4.2) | <0.001 | 82.3±10.2 | 2.8 (2.4 to 3.2) | <0.001 |
| Subtotal (n=27,987) | 133.3±17.3 | 4.3 (4.1 to 4.5) | <0.001 | 81.4±10.0 | 3.1 (3.0 to 3.2) | <0.001 |
| Wuhou | ||||||
| CCB (n=2,928) | 127.4±7.8 | −0.8 (−1.1 to −0.5) | <0.001 | 76.5±6.4 | −0.1 (−0.4 to 0.2) | 0.344 |
| D (n=132) | 128.2±6.8 | 1.4 (0 to 2.8) | <0.001 | 75.8±6.9 | 1.5 (−0.2 to 3.2) | 0.072 |
| BB (n=173) | 126.4±8.0 | –1.7 (−3.1 to −0.3) | 0.016 | 75.4±6.4 | −1.9 (−3.1 to −0.7) | 0.002 |
| ACEI (n=615) | 128.0±5.6 | 3.0 (2.2 to 3.8) | <0.001 | 76.0±5.8 | 1.2 (0.6 to 1.8) | <0.001 |
| ARB (n=217) | 127.5±7.1 | −0.6 (−1.8 to 0.6) | 0.320 | 76.5±6.4 | –0.7 (−1.8 to 0.4) | 0.184 |
| S1 (n=3) | 123.0±17.6 | −4.3 (−19.1 to 10.5) | 0.623 | 73.3±4.2 | −5.3 (−19.1 to 8.5) | 0.529 |
| C1 (n=674) | 126.2±8.0 | −1.8 (−2.6 to −1.0) | <0.001 | 75.1±6.3 | −1.7 (−2.3 to −1.1) | <0.001 |
| S2 (n=225) | 127.6±7.4 | −0.1 (−1.3 to 1.1) | 0.860 | 76.4±6.3 | −0.7 (−1.7 to 0.3) | 0.158 |
| Subtotal (n=4,967) | 127.3±7.5 | −0.4 (−0.7 to −0.1) | 0.005 | 76.3±6.3 | −0.3 (−0.5 to −0.1) | 0.022 |
| Total | ||||||
| CCB (n=27,016) | 135.7±18.0 | 5.3 (5.1 to 5.5) | <0.001 | 82.5±10.5 | 3.2 (3.1 to 3.3) | <0.001 |
| D (n=2,493) | 138.7±21.6 | 9.2 (8.4 to 10.0) | <0.001 | 84.3±11.5 | 5.2 (4.7 to 5.7) | <0.001 |
| BB (n=1,060) | 135.5±16.9 | 5.9 (4.8 to 7.0) | <0.001 | 82.0±9.8 | 3.1 (2.5–3.7) | <0.001 |
| ACEI (n=15,184) | 140.7±19.0 | 7.2 (6.9 to 7.5) | <0.001 | 85.6±11.0 | 3.9 (3.7 to 4.1) | <0.001 |
| ARB (n=1,492) | 136.4±17.1 | 5.0 (4.1 to 5.9) | <0.001 | 83.3±17.3 | 3.5 (2.9 to 4.1) | <0.001 |
| S1 (n=5,673) | 139.8±17.8 | 6.1 (5.6 to 6.6) | <0.001 | 85.2±10.4 | 2.9 (2.6 to 3.2) | <0.001 |
| C1 (n=4,051) | 143.5±20.9 | 7.3 (6.6 to 8.0) | <0.001 | 86.6±12.3 | 3.9 (3.5 to 4.3) | <0.001 |
| S2 (n=24,808) | 140.7±18.5 | 6.7 (6.5 to 6.9) | <0.001 | 85.5±10.6 | 3.3 (3.2 to 3.4) | <0.001 |
| Total (n=81,777) | 138.9±18.7 | 6.4 (6.3 to 6.5) | <0.001 | 84.4±10.8 | 3.5 (3.4 to 3.6) | <0.001 |
Notes:
a
Means with 95% confidence intervals. S1, fixed-dose single-pill combinations only including first-line drugs; S2, single-pill combinations including both first-line and non-first-line drugs; C1, multiple-pill combination of frst-line drugs.
Abbreviations: ACEI, angiotensin-converting enzyme inhibitors; ARB, angiotensin receptorblockers; BB, beta-blocker; BP, blood pressure; CCB, calcium channel antagonist; DBP, diastolic blood pressure; SBP, systolic blood pressure.