Table S1.

Risk of second primary cancers in ovarian cancer patients with or without a family history of concordant cancer, after removing high-risk families

Cancer site	Patients without ovarian cancer	Patients with ovarian cancer						P-trend value
		Negative family history			Positive family history
		N	RR	95% CI	N	RR	95% CI
UAT	3,769	12	1.12	0.64–1.97
Stomach	2,217	16	2.25	1.37–3.68	1	3.46	0.49–24.62	0.54
Small intestine	919	10	3.29	1.76–6.14
Colorectum	14,122	114	1.94	1.61–2.33	24	3.80	2.54–5.67	<0.001
Colon	9,965	86	2.04	1.65–2.52	14	4.80	2.94–8.11	<0.001
Rectum	5,090	37	1.82	1.32–2.51	1	1.42	0.20–10.11	0.33
Liver	3,178	21	1.84	1.20–2.82	1	3.17	0.45–22.5	0.32
Pancreas	3,905	36	2.40	1.73–3.33	3	8.58	2.77–26.62	0.52
Lung	13,327	74	1.47	1.17–1.85	12	3.43	1.95–6.04	<0.001
Breast	71,595	204	1.04	0.90–1.19	49	2.24	1.69–2.96	<0.001
Other female genitals	1,665	11	2.11	1.16–3.82
Kidney	4,130	21	1.64	1.07–2.53	1	2.59	0.36–18.38	0.32
Bladder	4,073	40	2.64	1.93–3.60	3	5.46	1.76–16.94	0.53
Melanoma	17,326	37	1.05	0.76–1.45	2	1.84	0.46–7.37	0.97
Skin (SCC)	6,692	20	0.76	0.49–1.17	3	3.30	1.06–10.23	0.06
Nervous system	12,083	16	0.70	0.43–1.14	1	1.57	0.22–11.14	0.29
Thyroid gland	4,635	10	1.60	0.86–2.98
Endocrine glands	6,938	22	1.38	0.91–2.10
Connective tissue	1,883	11	3.18	1.75–5.76	0
Non-Hodgkin lymphoma	6,492	17	0.88	0.55–1.42	1	1.49	0.21–10.58	0.32
Leukemia	7,053	29	1.70	1.18–2.45	0
CUP	5,491	51	2.59	1.97–3.42	3	4.08	1.32–12.66	0.56
All cancersa	94,104	360	1.52	1.37–1.68	734	1.77	1.64–1.90	<0.001
All cancersb	94,104	334	1.41	1.26–1.57	689	1.67	1.55–1.81	<0.001

Notes:

^aAll cancers including second ovarian cancer.

^bAll cancers excluding second ovarian cancer. Bold, italic and underlined values indicate that the 95% CI, 99% CI and 99.9% CI did not overlap with 1.00 respectively.

Abbreviations: CUP, cancer of unknown primary; RR, relative risk; SCC, squamous cell carcinoma; UAT, upper aerodigestive tract.