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. 2018 Oct 11;11:6827–6838. doi: 10.2147/OTT.S177639

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© 2018 O’Day et al. This work is published and licensed by Dove Medical Press Limited

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CMAS is elevated in TNBC.

Notes: (A) CMAS protein was detected in aggressive BPLER and MDA-MB468 TNBC cells, but not in HMLER by immunoblot. NANS, another Neu5Ac biosynthetic enzyme, was detected in all cell lines. Tubulin was used as a loading control. (B) TNBC patients were identified by identifying breast cancer patients with low levels of ESR1, PGR, and Her2 mRNA in TCGA. (C) Boxplot analysis confirmed the TNBC tumors have increased CMAS CNV and mRNA levels. Vertical axes display log2-transformed and normalized data according to mean centering for each gene across all samples.

Abbreviations: CMAS, cytidine monophosphate N-acetylneuraminic acid synthase; CNV, copy number variation; NANS, N-acetylneuraminic acid synthase; TCGA, The Cancer Genome Atlas.