Table 3.
Maximum RECIST response, CA 19-9 response
| Response | No of patients | %/range | |
|---|---|---|---|
|
| |||
| RECIST best tumor response | Overall response rate (CR + PR) | 32 | 36.8 |
| CR | 7 | 8.0 | |
| PR | 25 | 28.7 | |
| SD | 36 | 41.4 | |
| DCR (CR + PR+ SD) | 68 | 78.2 | |
| CA 19-9 parametersa | Nadir change, U/mL; Mean (range) | –4,077 | –43,065–18,845 |
| Decrease | |||
| >20% | 66 | 75.8 | |
| >50% | 49 | 56.2 | |
| >90% | 27 | 31.0 | |
| Time to response, months | 1 | 0.8–1.6 | |
Note:
a
Based on patients with baseline assessment above the upper limit of normal and at least one post-baseline CA 19-9 assessment.
Abbreviations: CA, carbohydrate antigen; CR, complete response; DCR, disease control rate; PR, partial response; RECIST, Response Evaluation Criteria in Solid Tumors; SD, stable disease.