Table 1. Univariate/multivariate Cox regression analysis of clinicopathologic factors associated with OS in TCGA cohort.
| Variables | Univariate analysis | Multivariate analysis | |||
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Risk score (> 8.9/≤ 8.9) | 1.910(1.250-2.919) | 0.003* | 1.617(1.021-2.560) | 0.040* | |
| TNM stage (I/II/III/IV) | 1.282(0.993-1.655) | 0.057 | — | — | |
| Hepatitis (HBV/HCV/neither) | 0.751(0.527-1.069) | 0.112 | — | — | |
| Alcohol consumption (yes/no) | 0.835(0.514-1.359) | 0.469 | — | — | |
| Gender (female/male) | 0.773(0.504-1.185) | 0.237 | — | — | |
| Age (>50/≤50) | 1.967(1.043-3.710) | 0.037* | 1.454(0.711-2.971) | 0.305 | |
| Cirrhosis (yes/no) | 0.865(0.471-1.587) | 0.639 | — | — | |
| Albumin (≤3.5/>3.5 g/dl) | 1.378(0.834-2.277) | 0.211 | — | — | |
| Creatinine (<1.1/≥1.1 mg/dl) | 0.739(0.455-1.199) | 0.221 | — | — | |
| AFP a (≤300/>300 ng/ml) | 0.900(0.513-1.582) | 0.715 | — | — | |
| Platelet (≤300/>300×109/L) | 0.753(0.466-1.216) | 0.246 | — | — | |
| Race (Asian/White) | 0.760(0.638-0.904) | 0.002* | 0.766(0.630-0.930) | 0.007* | |
| BMI b (≥25<25) | 1.028(0.650-1.626) | 0.905 | — | — | |
| Family history (yes/no) | 1.800(1.152-2.812) | 0.010* | 1.271(0.778-2.077) | 0.339 | |
| ECOG c | 1.406(0.956-2.066) | 0.083 | — | — | |
| Histological grade (G3-4/G1-2) | 1.247(0.802-1.938) | 0.327 | — | — | |
Abbreviations: OS, overall survival; HR, hazard ratio; 95% CI, 95% confidence interval.
*: Statistically significant;
a: Alpha-fetoprotein;
b: body mass index;
c: Eastern Cooperative Oncology Group.