Table 2. Univariate/multivariate Cox regression analysis of clinicopathologic factors associated with DFS in TCGA cohort.
| Variables | Univariate analysis | Multivariate analysis | |||
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Risk score (> 8.9/≤ 8.9) | 1.841(1.358-2.494) | <0.001* | 1.483(1.038-2.117) | 0.030* | |
| TNM stage (I/II/III/IV) | 1.727(1.441-2.070) | <0.001* | 1.568(1.274-1.929) | <0.001* | |
| Hepatitis (HBV/HCV/neither) | 0.943(0.760-1.170) | 0.592 | — | — | |
| Alcohol consumption (yes/no) | 1.061(0.767-1.468) | 0.720 | — | — | |
| Gender (female/male) | 0.982(0.711-1.355) | 0.911 | — | — | |
| Age (> 50/≤ 50) | 1.015(0.693-1.487) | 0.940 | — | — | |
| Cirrhosis (yes/no) | 1.271(0.861-1.877) | 0.228 | — | — | |
| Albumin (≤ 3.5/> 3.5 g/dl) | 1.033(0.702-1.519) | 0.870 | — | — | |
| Creatinine (< 1.1/≥ 1.1 mg/dl) | 0.739(0.511-1.069) | 0.109 | — | — | |
| AFP a (≤ 300/> 300 ng/ml) | 1.035(0.681-1.573) | 0.873 | — | — | |
| Platelet (≤ 300/> 300×109/L) | 1.415(0.976-2.052) | 0.067 | — | — | |
| Race (Asian/White) | 0.787(0.575-1.078) | 0.136 | — | — | |
| BMI b (≥ 25/< 25 kg/m2) | 0.882(0.643-1.211) | 0.437 | — | — | |
| Family history (yes/no) | 0.920(0.655-1.292) | 0.630 | — | — | |
| ECOG c | 1.697(1.406-2.049) | <0.001* | 1.389(1.138-1.695) | 0.001* | |
| Histological grade (G3-4/G1-2) | 1.186(0.867-1.621) | 0.286 | — | — | |
Abbreviations: DFS, disease-free survival; HR, hazard ratio; 95% CI, 95% confidence interval.
*: Statistically significant;
a: Alpha-fetoprotein;
b: body mass index;
c: Eastern Cooperative Oncology Group.