Table 4.
Determinants of Mus m 1 and Rat n 1 exposure in lab/operation rooms, animal rooms, and cage washrooms of Norwegian laboratory animal facilities.
| Ln Mus m 1 | B | SE | P | 95% CI | Effect | Ln Rat n 1 | B | SE | P | 95% CI | Effect |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lab/operation room (r 2 adj = 0.21) | Lab/operation room (r 2 adj = 0.74) | ||||||||||
| Intercept | −0.07 | 0.52 | 0.90 | −1.19 to 1.05 | Intercept | −2.12 | 0.09 | <0.001 | −2.33 to −1.92 | ||
| Bench type: LAF | −1.77 | 0.79 | 0.04 | −3.46 to −0.08 | 0.2 | Bench type: ventilated | 1.03 | 0.18 | <0.001 | 0.62 to 1.43 | 2.8 |
| Animal room (r 2 adj = 0.41) | Animal room (r 2 adj = 0.50) | ||||||||||
| Intercept | 3.65 | 0.46 | <0.001 | 2.72 to 4.57 | Intercept | −1.07 | 0.52 | 0.04 | −2.11 to −0.03 | ||
| Bench type: ordinary | −1.82 | 0.60 | 0.004 | −3.01 to −0.62 | 0.2 | Task: changing cages | 1.43 | 0.51 | 0.006 | 0.42 to 2.45 | 4.2 |
| Cage: IVC+ | −2.11 | 0.62 | 0.001 | −3.34 to −0.88 | 0.1 | Cage: IVC− | −2.22 | 0.38 | <0.001 | −2.98 to −1.47 | 0.1 |
| Cage: IVC− | −3.78 | 0.54 | <0.001 | −4.85 to −2.70 | 0.02 | Cage-racking system: open shelves with sliding doors | 2.65 | 0.82 | 0.002 | 1.16 to 4.28 | 14 |
| Cage washroom (r 2 adj = 0.71) | Cage washroom (r 2 adj = 0.75) | ||||||||||
| Intercept | 2.82 | 0.54 | <0.001 | 1.70 to 3.94 | Intercept | −1.73 | 0.36 | <0.001 | −2.47 to −0.99 | ||
| Cage: IVC+ | 5.08 | 0.85 | <0.001 | 3.31 to 6.84 | 160 | Cage: IVC+ | 3.24 | 0.62 | <0.001 | 1.95 to 4.53 | 26 |
| Cage-racking system: IVC | −2.73 | 0.79 | 0.002 | −4.37 to −1.09 | 0.07 | ||||||
| Cage-racking system: open shelves with sliding doors | 4.26 | 1.03 | 0.001 | 2.11 to 6.40 | 71 | Cage-racking system: open shelves with sliding doors | 6.12 | 0.76 | <0.001 | 4.54 to 7.69 | 455 |
The effect of the determinants, eB, where B is the coefficient of the determinant, is a factor that multiplied with eB for the intercept of the exclusive room will give the exposure effect of the determinant. That is, work in animal room with changing IVC− rat cages will give the following Rat n 1 exposure: eB(intercept for animal room) × eBTask: changing cages × eBCage: IVC negative = 0.3 × 4.2 × 0.1 = 0.13 ng m−3