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. 2018 Oct 15;13(10):e0205340. doi: 10.1371/journal.pone.0205340

Fig 5. Rhodomyrtone dose dependently decreases production of CXCL1, IL-36G, IL-36RN, MMP-13, S100A7, S100A8, and S100A12 transcripts by IL-17A/TNF-α-stimulated primary human keratinocytes.

Fig 5

Keratinocytes were pretreated with rhodomyrtone (50, 100, 200, 400, and 600 ng/ml) before stimulation with 20ng/ml IL-17A+10ng/ml TNF-α. The mRNA expression levels were measured at 24 h by qRT-PCR. Values are mean±SD of results from three independent experiments in triplicate. Statistical significance determined using one-way ANOVA and Dunnett’s multiple comparison test and noted ****p<0.0001, as compared with IL-17A/TNF-α treatment.