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. Author manuscript; available in PMC: 2018 Dec 15.

Published in final edited form as: Biochem Pharmacol. 2017 Sep 28;146:199–213. doi: 10.1016/j.bcp.2017.09.013

Figure 2. — microRNA response elements identified in the UGT2B7 3’-UTR (A-F) and UGT2B15 3’-UTR (G-U) by in silico analysis for the miRNAs shown to reducethe UGT2B7 and UGT2B15-dependent 3’-UTR luciferase reporter activity by at least 30% without affecting an empty luciferase reporter. Nucleotide positions in the mRNA are indicated relative to the last nucleotide of the stop codon. The binding free energy values (ΔG^o) between the miRNAs and the UGT2B7 and UGT2B15 3’-UTRs are expressed in kcal/mol and were calculated using RNAhybrid.

Figure 2. — microRNA response elements identified in the UGT2B7 3’-UTR (A-F) and UGT2B15 3’-UTR (G-U) by in silico analysis for the miRNAs shown to reducethe UGT2B7 and UGT2B15-dependent 3’-UTR luciferase reporter activity by at least 30% without affecting an empty luciferase reporter. Nucleotide positions in the mRNA are indicated relative to the last nucleotide of the stop codon. The binding free energy values (ΔG^o) between the miRNAs and the UGT2B7 and UGT2B15 3’-UTRs are expressed in kcal/mol and were calculated using RNAhybrid.