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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Hum Mutat. 2018 Nov;39(11):1593–1613. doi: 10.1002/humu.23630

Table 4a:

Recommendations for PP1 (segregation evidence)

General Recommendations
Supporting Moderate Strong
Likelihood 4:1 16:1 32:1
LOD Score 0.6 1.2 1.5
Autosomal
dominant
threshold
2 affected
segregations
4 affected
segregations
5 affected segregations
Autosomal
recessive
threshold
See Table 4b See Table 4b See Table4b