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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: FEBS Lett. 2018 Sep 20;592(19):3274–3285. doi: 10.1002/1873-3468.13236

Figure 7. Model depicting the uptake of exosome secreted in the absence or presence of fetuin-A.

Figure 7.

In the presence of fetuin-A, the exosomes secreted are easily taken up by other tumor cells or by the secreting cells (autocrine). Exosomes secreted in the absence of fetuin-A but presence of BSA, lack the capacity to enter the cells via syndecan 4 (SDC4) receptors. Uptake incompetent exosomes secreted in the absence of fetuin-A can be incubated with a mixture of fetuin-A and histones and after further purification are now competent to enter the cells via SDC4.