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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Ann Hum Genet. 2018 Jul 11;82(6):396–406. doi: 10.1111/ahg.12261

Table 1. Simulation Scenario 1 — The simulation model is the standard unidirectional mediation model.

The parameter estimates and the coverage percentages are based on 1000 replicates using the bidirectional and unidirectional mediation models.

Parameter True Value Bidirectional Mediation Model Uni-M-Y1
β12 0.75 0.76 (94.30%) 0.75 (94.20%)
β21 0.00 −0.01 (95.40%) 0.00 (100%)a
γ21 −0.25 −0.25 (95.90%) −0.25 (94.90%)
γ32 −0.25 −0.25 (95.80%) −0.25 (95.50%)
Direct Effect of X1 on Y2 0.75 0.75 (94.40%) 0.75 (92.60%)
Direct Effect of X1 on Y1 0.50 0.51 (96.10%) 0.50 (95.60%)
Indirect Effect of X1 on Y2 through Y1 0.38 0.38 (95.10%) 0.38 (93.80%)
Indirect Effect of X1 on Y1 through Y2 0.00 −0.03 (96.70%) 0.00 (100%)a

Uni-M-Y1 is the univariate mediation model: X1 is the initial variable, Y1 is the mediator, and Y2 is the outcome.

a

The parameters β21 and indirect effect of X1 on Y1 through Y2 are not modeled in the standard unidirectional model, Uni-M-Y1; therefore, these parameters are assumed to be zero.