Skip to main content
. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Biochem Pharmacol. 2018 Aug 2;156:10–21. doi: 10.1016/j.bcp.2018.07.043

Fig. 3. Steady-state kinetic profiles for Pathway 1 of terbinafine N-dealkylation.

Fig. 3.

N-Dealkylation of terbinafine yielded metabolic kinetics for two metabolites derived from Pathway 1 as illustrated in Fig. 1. The kinetic profiles include those for (A) TBF-A (dansyl hydrazine labeled) and (B) N-methyl-1-naphthyl methylamine (dansyl chloride labeled). Both sets of data were fit best to the Michaelis-Menten equation (p < 0.05), and the corresponding constants reported in Table 1. Twelve experimental reactions were carried out with terbinafine as substrate. Reaction conditions and data analysis were carried out as described in Materials and Methods.