Fig. 3.

(a) Schematic illustration of the dynamic peptide library system to search for supramolecular materials, which involves mixtures of dipeptides (input dyads), dynamic exchange of peptide sequences catalyzed by enzymatic condensation, hydrolysis, and transacylation, with the most-stable assembling structure eventually emerging (peptide nanostructure). The reaction conditions may be modified to promote or reduce certain supramolecular interactions and thermodynamic selection. (b) Potential energy surface that shows the formation of peptide oligomers. The depth of the wells represents the relative stability of the assembling peptides formed. Reprinted with permission from ref. 22 (Copyright 2016 Nature Publishing Group).