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. 2018 Oct 3;14(10):e1007692. doi: 10.1371/journal.pgen.1007692

Fig 2. SKAT-O analysis shows that TIMP3 variants are associated with BAV/TAD.

Fig 2

Manhattan plots showing the exome-wide significant finding that TIMP3 variants are associated with BAV, and with AR enlargement as an indicator of TAD. The horizontal line is the threshold for exome-wide significance (based on testing 19,392 genes, the exome-wide significance p-value = 2.578x10-6). TIMP3 is the only gene that exceeds exome-wide significance. It is notable that no other genes approach the significance line. A) Shows the association with BAV as the sole predictor (p = 1.58x10-6). B) Shows the association results for BAV and aortic root (AR) z-scores as covariates (p = 2.27x10-7). The significance level for TIMP3 increases nearly 10-fold when AR z-scores were added.